Tag Archives: science-history

Replaceable You by Mary Roach

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It’s another photograph of the penis [transplanted from the owner’s middle finger], now with a rustic ceramic pitcher hanging off of it. Exactly as you or I could put a hand out, palm up, and hang a pitcher off our middle finger. The pitcher is hand-painted, white with a red and green floral pattern. I’m picturing the man and his partner again, this time having lunch in the kitchen. A little iced tea, my love?

Eventually the day arrives when no further breach is possible. Mr. Baron, wrote his doctor, Richard Martland, “was now informed, the only chance for saving his life was by making an artificial anus . . . the inconveniences resulting from such operation, were candidly pointed out to him.” Mrs. White, on the occasion of her twelfth day without a bowel movement, is presented with the same proposition. Both patients consented. Or rather, as Pring put it, “did not violently object.” And so it went. “An opening was now made . . . and instantly a large quantity of liquid feces and wind escaped,” Martland wrote. Both doctors were impressed by the force with which the matter was expelled, with Pring taking additional note of the “considerable distance” traveled. – There was no mention of a fan in the vicinity.

This book certainly lends new meaning to the expression “an heir and a spare.”

I imagine many of us, certainly folks of my demographic, have had the experience of having parts replaced, probably because of need, but for some because of choice. I know I would happily have my begrudging spine replaced if I had the chance. And there are certainly a few improvements I could use that would be competing for second place on that list. Thus, my interest in Mary Roach’s latest, Replaceable You. (My ex can attest to the truth of the title’s applicability to the entire me.) Of course, I would read anything Mary Roach has written. She is one of my all-time favorite authors. And just in case her work is new to you, she combines a hard-reporting look at a particular scientific realm with a sense of humor that will leave you gasping for breath. Complete swallowing any ingested liquids before reading her work, as they may come blasting out your nose and mouth before you can get a grip. You have been warned.

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Mary Roach – image from Harvard Bookstore – shot by Jen Siska

Roach has made a career of writing about the human body, from conception (Boink) to grave (Stiff), and beyond (Spook), with travels through the alimentary canal (Gulp), the body’s reaction to space flight (Packing for Mars), to war (Grunt) and even to strangeness having to do with our interactions with animals (Fuzz). This time around, she covers a range of body parts subject to replacing. She sniffs out the history of nose jobs back to the 1500s, and lets us in on why they were in such high demand back then. She brings home the bacon by filling us in on the status of pig research (on, not by) for the purpose of developing organs that can be transplanted into humans, a subject close to my heart.

A formal “miniature swine development” project got underway in 1949, a collaboration between two Minnesota powerhouses, the Mayo Foundation (research arm of the Mayo Clinic) and the Hormel Institute (research arm of pork).

There are sections on the replacement, or enhancement, of sexual organs. One of the opening quotes of this review notes a particular form of actual, not kidding, replacement for a male member. Female anatomy comes in for a bit of consideration as well.

Dow Corning…made the first silicone breast implant, circa 1961, this one at the urging of Texas plastic surgeon Thomas Cronin. Cronin had been “inspired by the look and feel of a bag of blood.” It is hard for me not to picture the scene: Cronin standing around the OR, idly gazing at a bag hanging on a transfusion pole and turning to a colleague: Hey. Does that remind you of something? Cronin contacted Dow, and his resident, Frank Gerow, implanted some prototypes into dogs. The team were “excited” by the outcome—and again, stop me from picturing this.

Continuing downstairs…

Who looks at the human digestive tract and thinks, Moist, tubular, stretchy . . . Might that make a reasonable vagina?

Some, apparently. The derriere comes in for a long look as well. Part of this is a consideration of the changing fashions in tush shape, stretching from sane to anime.

I have made it (well in) to septuagenarian with what is probably an unremarkable range of replacement parts. My right arm was the recipient of two metal plates and a bone graft from my hip after a rather nasty industrial accident in 1970. The plates were removed once they had done their job of helping my bones knit, a few years later. The bone graft helped heal another fracture, and was eventually absorbed back into my skeleton.

Roach tells of prosthetic limbs, and the surprising news that some people prefer them to the original. In fact, the initial inspiration for this book came from a reader who had suggested that Mary take on the exciting world of football referees. Understandably, that failed to score, but it turned out that the woman, who has spina bifida, had a problem with her foot. It had, as a result of her other difficulties, become less than useless. She wanted it removed so she could get a prosthetic, but few surgeons would consider electively removing it. Mary joined her at the Amputation Coalition National Conference, and the game was…um…afoot.

It will come as no shock that using one’s own body bits as a source of transplantation offers the huge advantage of sparing you the need for a lifetime of immunosuppressive drugs. The body’s Studio 54 security guard can take a quick look and wave the new part in as the right sort. It worked for me a second time.

Other recent personal additions were the product of open-heart surgery, three stents and an aortic valve replacement. The stents were made up of material extracted from my right leg, and the valve was contributed by a member of our porcine community. I have yet to experience any desire to go digging for truffles in nearby woodlands.

Roach takes joy in comparing the techniques and tools of hip replacement surgery to woodworking, noting that while patients could actually be conscious during the surgery, the clanging, sawing machinery noise would be so disturbing that it is deemed preferable for patients to remain unconscious for the duration. She says that “Hip replacement has the visual drama of a visit to a Chevron station.”

Sadly, I was born with a mouthful of (well, maybe not born with, which would be weird, but ultimately host to a couple of sets, baby and adult) soft teeth (my dentist’s words). This led, over time, to a need for fillings, caps, bridges and dentures.
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If you count up all the teeth that are removed and replaced with implants or dentures, I bet they would lead the pack in sheer numbers of replacement bits. Mary leads us on a walk through dentures in history, the up and down sides, as well as the benefits of not using them at all. Yes, Geoge Washington makes an appearance. You will find the section on spring-loaded replacements both fascinating and alarming, and concerning as well is the fact that so many people have elected to remove healthy teeth in order to install dentures.

Replacing hair is big business these days. But not just up top. Pubic hair is also replaceable. Not only can the short and crinkly be replaced, with hair from the head, but the opposite can be done as well. Of course this can present some grooming challenges, as pubic and head hair grow differently and behave inconsistently when treated with grooming products. Mary subjected herself to a bit of hair harvesting in her travels.

My donor site is smeared with bacitracin, but no gauze is taped in place, because my hair would get stuck. On the flight home, I will feel the back of my head start to ooze. Do you fly Southwest? Don’t sit in 11B.

She delves into the growth industry of 3D printing of bodily materials. It turns out that it is not so simple as it might seem. Each muscle and organ has particular abilities and behaviors that are very difficult to replicate, involving twisting, contracting, and reacting to incoming messaging from the brain. The Star Trek replicator might do a great job of producing “Earl Grey, hot,” but fabricating people-pieces is proving a much more complex undertaking than sci-fi writers imagined.

Eye lenses are being replaced at increasing rates. There are even many people who, as with tooth replacement noted above, are having their natural lenses replaced in order to improve their vision.

I have worn glasses since I was eight years old, for distance. The only issue I had with them was losing track of them. But in the last few years, it became obvious that there was a buildup of material on the left lens of my eye (not just the product of inattentive eyeglass wiping) that made night driving particularly challenging. Oncoming headlights, even non-bright ones, spread a glare across my field of view that was problematic. I had cataract surgery earlier this year (2025), left eye only. And it worked like a squeegee on a filthy window. The headlights are still miserable, particularly when people insist on using their brights, and when many newer cars use lights that are brighter than the prior generations of illumination, but the improvement in my vision was immediate.

She writes about the processes involved in recovering bio-materials from the recently dead, the potential for banking our own cells as a source for future replacement materials, a machine for offloading heart and respiration work from the body temporarily, and introducing us to the wonderful world of ostomies, noted up top.

Mary may write about science, but she is not, per se, a scientist. Thus, she can offer us an every-person view into the subjects she investigates. She reacts how we might react when faced with the same discoveries. She brings the oh, wow!, the joy-of-discovery moments to life for readers, and thus makes what she has learned stick for us more than it would from any dry textbook. If she leaves you in stitches, that might just be a part of your replacement work. If you burst with laughter, bust a gut, if you crack up or your laughter is side-splitting, that may be why you needed the work in the first place. Of course, if you laugh your head off, there is probably no short-term solution to that. Replaceable You is the real thing, as is Mary Roach. She is one of a kind. Accept no substitute. She is irreplaceable.

Nana takes a seat at Kuzanov’s desk and starts opening files on his computer desktop. After a few false starts, she locates a folder of photographs documenting a finger transplant performed on a cancer patient. Most of the man’s penis had been amputated, leaving him unable to do two of the things most men like to do with their penis: penetrate and pee while standing. The surgery would restore both. – She missed one.

Review posted – 09/19/25

Publication date – 09/16/25

I received an ARE of Replaceable You from W.W. Norton & Company in return for a fair review. Thanks, folks, and thanks to NetGalley for facilitating. And could you check to see if anyone left any spare spines lying around.

This review is cross-posted on Goodreads. Stop by and say Hi!

===================================EXTRA STUFF

Links to Roach’s personal, Instagram and Twitter pages

Profile – from her site

I grew up in a small house in Etna, New Hampshire. My neighbors taught me how to drive a Skidoo and shoot a rifle, though I never made much use of these skills. I graduated from Wesleyan in 1981 and drove out to San Francisco with some friends. I spent a couple years working as a freelance copy editor before landing a half-time PR job at the SF Zoo. On the days when I wasn’t there in my little cubicle in the trailer behind Gorilla World, I freelanced articles for the Sunday magazine of the local newspaper. One by one, my editors would move on to bigger publications and take me along with them. In the late 1990s, magazines began to sputter out and travel budgets evaporated, and so I switched to books.
People call me a science writer, though I don’t have a science degree and sometimes have to fake my way through interviews with experts I can’t understand.
I have no hobbies. I mostly just work on my books and hang out with my family and friends. I enjoy bird-watching (though the hours don’t agree with me), hiking, backpacking, overseas supermarkets, Scrabble, mangoes, and that late-night “Animal Planet” show about horrific animals such as the parasitic worm that attaches itself to fishes’ eyeballs but makes up for it by leading the fish around.

Interviews
—–Stuff to Blow Your Mind on iHeart – Replaceable You, with Mary Roach by Robert Lamb – audio (36 minutes) with available transcript
—–Peculiar Book Club – MARY ROACH is Un-Replaceable! – video – 1:10:03 – from 5:00
—–NPR – From heart to skin to hair, ‘Replaceable You’ dives into the science of transplant with Brandy Shillace
—–Association of Health Care Journalists – Mary Roach calls herself ‘the gateway drug to science’ by Lesley McClurg

Other Mary Roach books we have enjoyed
—–2021 – Fuzz: When Nature Breaks the Law
—–2016 – Grunt: The Curious Science of Humans at War
—–2013 – Gulp
—–2010 – Packing for Mars
—–2006 – Spook Six Feet Over – recently renamed
—–2004 – Stiff

Items of Interest
—–New York Times – 10 Icky Things Mary Roach Has (Unfortunately) Brought to My Attention – by Sadie Stein – from sundry MR writings, in case you have not laughed enough from reading her latest
—–Bauman Medical – What is a Pubic Hair Transplant?
—–Youtube – A particularly disturbing transplantation scene from the 1973 film Oh Lucky Man

Song
—–Beyonce – Irreplaceable

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Filed under History, Non-fiction, Public Health, Science and Nature

Genius Makers by Cade Metz

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[In 2016] Ed Boyton, a Princeton University professor who specialized in nascent technologies for sending information between machines and the human brain…told [a] private audience that scientists were approaching the point where they could create a complete map of the brain and then simulate it with a machine. The question was whether the machine, in addition to acting like a human, would actually feel what it was like to be human. This, they said, was the same question explored in Westworld.

AI, Artificial Intelligence, is a source of active concern in our culture. Tales abound in film, television, and written fiction about the potential for machines to exceed human capacities for learning, and ultimately gain self-awareness, which will lead to them enslaving humanity, or worse. There are hopes for AI as well. Language recognition is one area where there has been growth. However much we may roll our eyes at Siri or Alexa’s inability to, first, hear, the words we say properly, then interpret them accurately, it is worth bearing in mind that Siri was released a scant ten years ago, in 2011, Alexa following in 2014. We may not be there yet, but self-driving vehicles are another AI product that will change our lives. It can be unclear where AI begins and the use of advanced algorithms end in the handling of our on-line searching, and in how those with the means use AI to market endless products to us.

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Cade Metz – image from Wired

So what is AI? Where did it come from? What stage of development is it currently at and where might it take us? Cade Metz, late of Wired Magazine and currently a tech reporter with the New York Times, was interested in tracking the history of AI. There are two sides to the story of any scientific advance, the human and the technological. No chicken and egg problem to be resolved here, the people came first. In telling the tales of those, Metz focuses on the brightest lights in the history of AI development, tracking their progress from the 1950s to the present, leading us through the steps, and some mis-steps, that have brought us to where we are today, from a seminal conference in the late 1950s to Frank Rosenblatt’s Perceptron in 1958, from the Boltzmann Machine to the development of the first neural network, SNARC, cadged together from remnant parts of old B-24s by Marvin Minsky, from the AI winter of governmental disinvestment that began in 1971 to its resumption in the 1980s, from training machines to beat the most skilled humans at chess, and then Go, to training them to recognize faces, from gestating in universities to being hooked up to steroidal sources of computing power at the world’s largest corporations, from early attempts to mimic the operations of the human brain to shifting to the more achievable task of pattern recognition, from ignoring social elements to beginning to see how bias can flow through people into technology, from shunning military uses to allowing, if not entirely embracing them.

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This is one of 40 artificial neurons used in Marvin Minsky’s SPARC machine – image from The Scientist

Metz certainly has had a ringside seat for this, drawing from hundreds of interviews he conducted with the players in his reportorial day jobs, eight years at Wired and another two at the NY Times. He conducted another hundred or so interviews just for the book.

Some personalities shine through. We meet Geoffrey Hinton in the prologue, as he auctions his services (and the services of his two assistants) off to the highest corporate bidder, the ultimate figure a bit startling. Hinton is the central figure in this AI history, a Zelig-like-character who seems to pop up every time there is an advance in the technology. He is an interesting, complicated fellow, not just a leader in his field, but a creator of it and a mentor to many of the brightest minds who followed. It must have helped his recruiting that he had an actual sense of humor. He faced more than his share of challenges, suffering a back condition that made it virtually impossible for him to sit. Makes those cross country and trans-oceanic trips by train and plane just a wee bit of a problem. He suffered in other ways as well, losing two wives to cancer, providing a vast incentive for him to look at AI and neural networking as tools to help develop early diagnostic measures for diverse medical maladies.

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Marvin Minsky in a lab at M.I.T. in 1968.Credit…M.I.T. – image and caption from NY Times

Where there are big ideas there are big egos, and sometimes an absence of decency. At a 1966 conference, when a researcher presented a report that did not sit well with Marvin Minsky, he interrupted the proceedings from the floor at considerable personal volume.

“How can an intelligent young man like you,” he asked, “waste your time with something like this?”

This was not out of character for the guy, who enjoyed provoking controversy, and, clearly, pissing people off. He single-handedly short-circuited a promising direction in AI research with his strident opposition.

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Skynet’s Employee of the month

One of the developmental areas on which Metz focuses is deep learning, namely, feeding vast amounts of data to neural networks that are programmed to analyze the incomings for commonalities, in order to then be able to recognize unfamiliar material. For instance, examine hundreds of thousands of images of ducks and the system is pretty likely to be able to recognize a duck when it sees one. Frankly, it does not seem all that deep, but it is broad. Feeding a neural net vast quantities of data in order to train it to recognize particular things is the basis for a lot of facial recognition software in use today. Of course, the data being fed into the system reflects the biases of those doing the feeding. Say, for instance, that you are looking to identify faces, and most of the images that have been fed in are of white people, particularly white men. In 2015, when Google’s foto recognition app misidentified a black person as a gorilla, Google’s response was not to re-work its system ASAP, but to remove the word “gorilla” from its AI system. So, GIGO rules, fed by low representation by women and non-white techies. Metz addresses the existence of such inherent bias in the field, flowing from tech people in the data they use to feed neural net learning, but it is not a major focus of the book. He addresses it more directly in interviews.

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Frank Rosenblatt and his Perceptron – image from Cornell University

On the other hand, by feeding systems vast amounts of information, it may be possible, for example, to recognize early indicators of public health or environmental problems that narrower examination of data would never unearth, and might even be able to give individuals a heads up that something might merit looking into.

He gives a lot of coverage to the bouncings back and forth of this, that, and the other head honcho researcher from institution to institution, looking at why such changes were made. A few of these are of interest, like why Hinton crossed the Atlantic to work, or why he moved from the states to Canada, and then stayed where he was based once he settled, regardless of employer. But a lot of the personnel movement was there to illustrate how strongly individual corporations were committed to AI development. This sometimes leads to odd, but revealing, images, like researchers having been recruited by a major company, and finding when they get there that the equipment they were expected to use was laughably inadequate to the project they were working on. When researchers realized that running neural networks would require vast numbers of Graphics Processing Units, GPUs (comparable to the Central Processing Units (CPUs) that are at the heart of every computer, but dedicated to a narrower range of activities) some companies dove right in while others balked. This is the trench warfare that I found most interesting, the specific command decisions that led to or impeded progress.

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Rehoboam – the quantum supercomputer at the core of WestWorld – Image from The Sun

There are a lot of names in The Genius Makers. I would imagine that Metz and his editors pared quite a few out, but it can still be a bit daunting at times, trying to figure out which ones merit retaining, unless you already know that there is a manageable number of these folks. It can slow down reading. It would have been useful for Dutton to have provided a graphic of some sort, a timeline indicating this idea began here, that idea began then, and so on. It is indeed possible that such a welcome add-on is present in the final hardcover book. I was working from an e-ARE. Sometimes the jargon was just a bit too much. Overall, the book is definitely accessible for the general, non-technical, reader, if you are willing to skip over a phrase and a name here and there, or enjoy, as I do, looking up EVERYTHING.

The stories Metz tells of these pioneers, and their struggles are worth the price of admission, but you will also learn a bit about artificial intelligence (whatever that is) and the academic and corporate environments in which AI existed in the past, and is pursued today. You will not get a quick insight into what AI really is or how it works, but you will learn how what we call AI today began and evolved, and get a taste of how neural networking consumes vast volumes of data in a quest to amass enough knowledge to make AI at least somewhat…um…knowledgeable. Intelligence is a whole other thing, one of the dreams that has eluded developers and concerned the public. It is one of the ways in which AI has always been bedeviled by the curse of unrealistic expectations.

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(left to right) Yann LeCun, Geoffrey Hinton, Yoshua Bengio – Image from Eyerys

Metz is a veteran reporter, so knows how to tell stories. It shows in his glee at telling us about this or that event. He includes a touch of humor here and there, a lightly sprinkled spice. Nothing that will make you shoot your coffee out your nose, but enough to make you smile. Here is an example.

…a colleague introduced [Geoff Hinton] at an academic conference as someone who had failed at physics, dropped out of psychology, and then joined a field with no standards at all: artificial intelligence. It was a story Hinton enjoyed repeating, with a caveat. “I didn’t fail at physics and drop out of psychology,” he would say. “I failed at psychology and dropped out of physics—which is far more reputable.”

The Genius Makers is a very readable bit of science history, aimed at a broad public, not the techie crowd, who would surely be demanding a lot more detail in the theoretical and implementation ends of decision-making and the construction of hardware and software. It will give you a clue as to what is going on in the AI world, and maybe open your mind a bit to what possibilities and perils we can all look forward to.

There are many elements involved in AI. But the one (promoted by Elon Musk) we tend to be most concerned about is that it will develop, frighteningly portrayed in many sci-fi films and TV series, as a dark, all-powerful entity driven to subjugate weak humans. This is called AGI, for Artificial General Intelligence and is something that we do not know how to achieve. Bottom line for that is pass the popcorn and enjoy the show. Skynet may take over in one fictional future, but it ain’t gonna happen in our real one any time soon.

Review first posted – April 16, 2021

Publication dates
———-Hardcover – March 16, 2021
———-Trade Paperback – February 15, 2022

I received an e-book ARE from Dutton in return for…I’m gonna need a lot more data before I can answer that accurately.

This review has been cross-posted on GoodReads

=======================================EXTRA STUFF

Links to the author’s personal, FB, and Twitter pages

Interview
—–C-Span2 – Genius Makers with Daniela Hernandez – video – 1:28:17 – this one is terrific

Other Reviews
—–Forbes – The Mavericks Who Brought AI to the World – Review of “Genius Makers” by Cade Metz by Calum Chace
—–Fair Observer – The Unbearable Shallowness of “Deep AI” By William Softky • Mar 31, 2021
—– Christian Science Monitor – Machines that learn: The origin story of artificial intelligence By Seth Stern

Items of Interest from the author
—–A list of Metz’s New York Times articles
—–A list of Metz’s Wired articles
—–excerpt
—–NY Times – Can Humans Be Replaced by Machines? by James Fallows

Items of Interest
—–Public Integrity – Are we ready for weapons to have a mind of their own? by Zachary Fryer-Biggs
—–Wiki on Geoffrey Hinton
—–Wiki for Demis Hassabis
—–Cornell Chronicle – Professor’s perceptron paved the way for AI – 60 years too soon by Melanie Lefkowitz
—–The Scientist – Machine, Learning, 1951 by Jef Akst

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Filed under AI, American history, Artificial Intelligence, business, computers, History, Non-fiction, programming