Tag Archives: neuroscience

Seven Deadly Sins by Guy Leschziner

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The ebb and flow of human history is defined by the Seven Deadly Sins: wrath, gluttony, lust, envy, sloth, greed, and pride. From the wrath that has ignited revolutions, to the greed that has re-sculpted the world map. From the sloth that has led to the fall of empires, to the envy that has built them. From the lust that has led to the fall of politicians and the betrayal of national secrets, to the voracious gluttony that has left our environment in ruination, and the pride that has fueled countless conflicts.

Disorders of the brain, of our genes, or other physical conditions, may give rise to gluttony, lust, wrath or pride. The effects of our environment or our upbringing may produce envy, lust or sloth. Crucially, these disorders unmask what is already in us, what already exists in all of us.

William J. Bennet (before he was outed as a compulsive gambler) is reputed to have said “One man’s vice is another man’s virtue.” Pope Gregory, in the sixth century CE, had a different idea, whittling a larger, earlier list down to seven deadly sins. (One wonders if there might be a grander list of [insert number here] bloody annoying sins). I do remember in my Catholic grammar school days Monsignor Marshall giving a sermon on venial sin (non-deadly, but as far as I can recall not presented as a list), in which he offered up the image of Jesus on the cross, and proclaimed that committing a venial sin was like slapping the nailed Christ across the face, albeit not very hard. No Jewish mother ever delivered a more impactful guilt trip.

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Professor Guy Leschziner – image from The Daily Mail

In his prior book, The Man Who Tasted Words, Professor Leschziner looked at places where the lines between our senses appear to be somewhat porous, sense-A leaking into sense-B for some individuals. Hearing colors, seeing sounds, aphasic things like that. He offered an examination of what is considered usual, and where, in the brain, wires may have become crossed. He looked at individuals who reported such experiences and attempted to trace back into the brain where each sense resided, and connected to others.

Here he uses as his starting point the notion of the seven deadly sins, and offers neurological analysis of behaviors commonly regarded as sinful. Bu the Seven Deadly sins seem to divide into two groups, one based on behavior and one based on emotion. Wrath, Gluttony, Sloth and Greed require action to do actual damage, while Pride, Envy and Lust can remain internal. You may think you are better than everyone else, but unless you do something based on that belief, it makes no difference. Ditto Lust and Envy. In the absence of acting on these feelings, no harm, no foul, so the playing field for looking at The Seven is uneven from the start. The subtext is the question of free will. Are we all functional free agents able to determine right from wrong or are we driven by our biology, by what our brains have, by genetic heritage and experiential conditioning, commanded us to do? And how have the behaviors that have defined our species, that have led to our accomplishments as well as our excesses, our failings, served us? Is there a range within which our less than idyllic urges can function healthfully, and outside of which they constitute pathology?

Look at aberrant behavior. Dive in to see exactly which parts of the brain have been harmed, if any. Map behaviors, needs, urges, inclinations to parts of the brain. In a way, this is a bit like explorations of yore, sailing out to see what lay over the horizon, or, fictionally, heading out on a starship to see what the universe may present. He uses several case studies of people who manifest behaviors illustrative of each of the sins, looking for neurological bases. Just as in his examination of cross-sense irregularities in his prior book, Leschziner looks at these patients with an eye toward identifying which parts of the brain bear the most responsibility for the problematic behaviors. These include a man who had had a brain bleed that changed his personality, a woman who was incapable of feeling satisfied no matter how much she ate, a 34yo man with Parkinson’s and an increasing obsession with sex, a woman who believes her totally faithful husband is cheating on her, a young father who sleeps twenty hours a day, a man has delusions of grandeur until multiple abscessed teeth are removed, oh, and the Panama Papers. Centers of emotional concern include the amygdala, the pre-frontal cortex, a warrior gene, and the hypothalamus internally. He looks at the influence of bacteria, viruses, dopamines, and more impacting from the outside. Increasingly, science can indeed offer some answers to the why of behaviors, to a point.

In his novel, Fleur de Lis, Anatole France wrote. “The law, in its majestic equality, forbids rich and poor alike to sleep under bridges, to beg in the streets, and to steal bread.” There are clearly hypocritical societal interpretations of sin, of what sinful behaviors will be tolerated and which will be sanctioned. (Unless, of course, you are a president with a friendly Congress and SCOTUS, in which case, just go ahead with whatever you are doing there on Fifth Avenue.)

Poor man wanna be rich, rich man wanna be king
And a king ain’t satisfied till he rules everything
– Springsteen – Badlands

And most societies assign moral responsibility to the actor. The question is whether a person is morally responsible for his/her actions or is a slave to, and predetermined by impulses, by one’s underlying and overwhelming personal psychological makeup.

if you believe that the brain is the origin of our personalities and our character traits, the basis of our decisions, be they good or bad, then it is arguable that much of what defines us is outside of our control.

Whether we are all able to make actual free choices or are slaves to our biology, it is clear that society needs to be able to restrict our ability to harm each other, that protecting each other from the worst in people is a reasonable social responsibility.

It is made clear that the drives that we regard as sinful have provided considerable benefit to our evolution as a species. No lust? No reproduction. No envy? No reason to be more productive. No wrath? No defense against attack.

Leaving the question of evil. At first blush is seems that evil serves no obvious Darwinian purpose. On second thought, though, I expect there might be a case made for evil existing as an existential challenge in order to provide a testing ground against which one might measure strength of character and/or the superiority of one’s genes, whether physical or intellectual. In a way, like ice ages, rapid climate change, or a voracious saber-tooth tiger, evil might be seen as a natural force, even if it manifests through human beings.

Leschziner has offered up a provocative, thoughtful brain-candy-ish look at how science, as it advances, keeps finding biological explanations for fraught psychological behaviors. But our impulses and makeup remain what they are. And this is one of the pleasures of reading The Seven Deadly Sins. Learning what a strange creature is homo sapiens, and how we are put together. It seems quite clear that the real original sin is to have been born human.

extrinsic factors – medication, injury, or functional disturbance of the brain – rather than our values can cause us to act in ways that contravene our moral
code. However, that dividing line between what constitutes normality and pathology shifts in the sand. That line is blurred by the prevailing winds of our views on morality, legality, philosophy and medicine.

Review posted – 02/21/25

Publication date – 12/3/24

I received paper and ePub AREs of Seven Deadly Sins from St Martin’s in return for a fair review. Thanks, folks, and thanks to NetGalley for facilitating.

This review is cross-posted on Goodreads. Stop by and say Hi!

=======================================EXTRA STUFF

Links to the author’s personal, Instagram, and Twitter pages
Profile

Interviews
The Guardian – Science Weekly Podcast – Are we hardwired to commit ‘deadly sins’? – podcast
– audio – 23:59
—–The Jewish Chronicle – Were the Nazis inherently evil? ByJennifer Lipman
—–Greed, gluttony, sloth…lust! Why you sinned this Christmas by Anna Maxted

Items of Interest from the author
—–Big Issue – The truth is we’re all sinners – it’s how we survive as human beings
—–Next Big Idea Club – A Scientific Examination of the Seven Deadly Sins

My review of the author’s prior book
—–2022 – The Man Who Tasted Words

=======================EXTRA EXTRA STUFF

George Carlin famously distilled the ten commandments down to two.

It seems pretty clear that the seven deadly sins can likewise be slimmed down as well.

Pride. What does this actually mean?
Believing that you are better than other people? What if you are? Faster, stronger, better looking, smarter. Something more than others. Is recognizing your superiority a sin if it is true? The bible seems to maintain that an “Excessive” self-regard is where the line is crossed, but who gets to determine where the line is drawn between factual and excessive self-regard?

But pride does seem to be a pre-condition for other sins. Wrath, or extreme anger, certainly seems an appropriate response to extreme provocation. Hardly a sin. But in order to get into a sinful bit of wrathful behavior it must be excessive. In order for it to be excessive the deliverer of such wrath must hold a higher view of him or herself vis a vis the target than seems justifiable. Soooo, excessive pride, right? So, scratch wrath, and we are down to six.

Gluttony – excessive consumption to the point of waste.
Wiki tells us that In Christianity, it is considered a sin if the excessive desire for food leads to a lack of control over one’s relation with food or harms the body. But if the desire for food entails loss of control over one’s relation to food, where is free will? Isn’t that a definition of pathology? And a pathological behavior is hardly sinful. And just what constitutes excessive desire? If we remove the pathological from this formula, we are left with a person feeling entitled to consume (and I think it is safe to expand the notion of consumption here from food to all things material) as if they are better or more deserving of such things. Which brings us back to pride. Gluttony eats itself into a coma and we are down to five.

Greed
Catholic.com claims that Greed is the disordered love of riches. Hmmm, who gets to define “disordered?” and doesn’t a love of riches include a personal belief that one deserves such riches? Here we go again. It requires excessive self-regard to crave riches at a “disordered” level, no? Greed crushes itself with massive accumulation of stuff and we are left with four.

For these other sins, we delineate the pathologies that shape our thoughts and behaviours, and set them apart from those underlying character traits through their intensity and consequences. For greed, we do no such thing. Yet greed, like the other sins, is perilous in its most extreme forms, causing harm to individuals and wider society alike.

Is Donald Trump, a career criminal, capable of differentiating between right and wrong, or was he so damaged by his genetics and upbringing and injured by his subsequent business training at the feet of his sociopathic father, that he is incapable of telling or even caring about the difference between good and bad? Similar for Elon Musk. How great would it be were Leschziner able to do a detailed examination of both men’s brains. Because if they are capable of discriminating right from wrong, then we have a pretty clear proof that there are indeed forces of evil loose in the world, which I expect would come as a great shock to few but the most ardent atheists.

Lust and envy seem sub-elements of the same thing, wanting something that someone else has. Surely lust between two unattached people is no sin. It is only when one person (at least) is already attached that lust becomes problematic (presuming a monogamous baseline). So, wanting something (someone) who/which is not yours, but which is attached to, or is owned by someone else. So what? We all want stuff we do not or cannot have. How is this a sin? It seem to me that having feelings like lust and envy is completely natural. It is only when we take actions to effectuate such the desire, to the detriment of others that the sin element is realized. Down to two.

According to Wikipedia Sloth is the most difficult sin to define and credit as sin, since it refers to an assortment of ideas, dating from antiquity and including mental, spiritual, pathological, and conditional states. One definition is a habitual disinclination to exertion, or laziness. Willful laziness is surely not cool. Just ask any married person whose partner declines to hold up his or her end, opting instead to watch football or soaps. This one seems likely to be based in behavior, as the sinner here engages in slothful behavior, doesn’t just feel…um…slothful. I could certainly see many real-world examples, beyond couch potato chore-avoiders. There are many people who cannot be bothered exercising the intelligence they were born with to examine themselves, their community, public issues, religious beliefs, or much of anything. It may well be that they believe themselves not up to such analysis, and maybe they are not. But for many, if not all, it does seem that the disinclination rests on a belief that they are too good to have to bother with such things, that they have it all figured out and need look no further than the perimeter of their personal bubble…so…excessive pride. And poof! We are down to one.

Pride goeth before the fall, and, apparently every other form of sinfulness. There is only one deadly sin, excessive self-regard, which feeds all the others, and becomes problematic only when put into actual real-world action.

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Filed under Non-fiction, Psychology and the Brain, Public policy, Science and Nature

A Taste for Poison by Neil Bradbury

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… a chemical is not intrinsically, good or bad, it’s just a chemical. What differs is the intent with which the chemical is used: either to preserve life – – or to take it.

Within the annals of crime, murder holds a particularly heinous position. And among the means of killing, fewer methods generate such a peculiar morbid fascination as poison. Compared with hot blooded spur of the moment, murderers, the planned and cold calculations involved in murder by poison, perfectly fit the legal term malice aforethought. Poisoning requires planning and knowledge of the victim’s habits. It requires consideration of how the poison will be administered. Some poisons can kill within minutes; others can be given slowly, over time, gradually accumulating in the body, but still leading inexorably to the victim’s death.

If you are a fan of True Crime, if you are a fan of TV procedurals, if you are a fan of murder mysteries, A Taste for Poison is a must read. You will be much better prepared to keep up with the medical examiners in all venues when you can recognize the victims’ symptoms, at least if the book or show gives you a chance to try figuring it out for yourself before the truth is revealed.

Neil Bradbury grew up fascinated by murder mysteries and poisons. He is a graduate of the University of St. Andrews in Scotland, and the University of Wales School of Medicine, with degrees in Biochemistry and Medical Biochemistry. Although he grew up in the UK, he now lives and works in Illinois, USA, where he’s a scientist, teacher and writer. He also gets to play with nasty chemicals every day (during scientific experiments of course). – from his site

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Dr. Neil Bradbury – image from his site

He has carefully mixed his interests and profession to produce a fun, informative look at poisons through the ages. One might wonder if he wrote the book using a poison pen. I wouldn’t, but some might. He includes looks at the following: Aconite, Arsenic, Atropine, Chlorine, Cyanide, Digoxin, Insulin, Potassium, Polonium, Ricin, and Strychnine. None would qualify as pretty, although cyanide does gift its victims with a lovely ruddy complexion.

One of the primary themes of the book is that poisoning is the misapplication of healing pharma to dark purpose. Think water. Necessary for human survival, comes in many forms. These days it forms a base layer for a surface layer of every imaginable flavor, nifty literary tool too, right? But water-boarding, or tsunami? Not so much.

Bradbury goes through the medically helpful aspects of multiple poisons, then shows how they have been used to kill, who used them, on whom they were used, how the crimes were figured out and prosecuted, and what happened to the poisoners. In doing this he provides us with a history of when it became possible to diagnose (detect) each poison as a murder weapon, (of particular interest in historical mystery dramas) and details the biology of how each works its dark arts inside the human body.

Sadly, for those with a poison-based homicidal urge, the subjects of Bradbury’s reporting, for the most part, were tried and convicted. And today, in the absence of governments protecting state-sponsored poisoners, very few such crimes go unpunished.

You are unlikely to recognize the names here, at least the names of the killers, attempted killers, and victims, but as with many in the history of medicine, that is not unusual. Nevertheless, the details are here, as many crimes are examined.

Bradbury offers a fun collection of historical odds and ends, like how the telegraph, newly in service, foiled the escape of one poisoner. Or how one particular poison may have been at the root of vampire mythology, or how strychnine was used as a pick-me-up in the early 20th century, or the surprising cost of manufacturing polonium, and even a new take on some Van Goh masterpieces.

The only downside for me was that I tended to get a bit lost in the sections detailing the biological and chemical workings of these substances inside the body. I would not say they are extremely technical. I would say that I was always complete garbage at chemistry, and not a whole lot better at biology, so may have nurtured a disaffection that is unlikely to affect you the same way. There is some humor in the book, but not a whole lot.

Still, As a consumer of a considerable amount of crime-based entertainment, I was particularly drawn to this book. The how-dun-it often is as important as the who, and by detailing victim symptomology as well as poisoner and investigator methodologies, we can all get a greater appreciation for the challenges entailed. I may not have had the right chemical receptors for the scientific details, but there is plenty of intel in here that will enhance your engagement in crime shows, and teach you a bit about the history of these substances, many of which exist in common parlance. So, it may or may not be for you. I guess you will just have to pick your poison.

…in France in the late 1600s, the effectiveness of arsenic and disposing of wealthy relatives who had the temerity to remain alive, was so widespread that it gained the name Poudre de succession, or “inheritance powder.”

Review posted – 11/17/23

Publication dates
———-Hardcover – 2/1/22
———-Trade paperback – 8/15/23

I received a paperback of A Taste for Poison from Griffin in return for a fair review. I am happy to report that the tingling feeling in my hands, which began after I first began to read the book, soon abated. Thanks, folks, and thanks to NetGalley for facilitating.

This review is cross-posted on my site, Goodreads. Stop by and say Hi!

=======================================EXTRA STUFF

Links to the author’s personal and Goodreads author pages

Alas, as far as I was able to find, Bradbury’s on-line presence is slender, limited to his personal site and GR author page. Maybe laying low after having taken care of some personal rivals?

Interview
—–Murder & MayhemTalking Poisons with Dr. Neil Bradbury

Items of Interest
—–Listverse – Top 10 Remorseless Poisoners That History Almost Forgot by Radu Alexander
—–Philadelphia Inquirer –A Pennsylvania nurse is accused of killing 4 patients, injuring others with high doses of insulin by Bruce Shipkowski and Brooke Schultz, Associated Press
—–Wikipedia – List of Poisonings through history – from 399 BC to 2021 – a nifty list

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Filed under History, Non-fiction, Science and Nature, True crime

Nineteen Ways of Looking at Consciousness by Patrick House

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The brain…is a thrift-store bin of evolutionary hacks Russian-dolled into a watery, salty piñata we call a head.

…consciousness is not something passed on or recycled–like single molecules of water, which are retained as they move about the earth as ice, water, or dew–from one living creature to the next…instead consciousness should be grown from “scratch” with only a few well-timed molecular parts from plans laid out. It is not drawn from a recycled tap of special kinds of cells or dredged from the vein of free will. No, the darn thing grows. From its own rules. All by itself. And we have no idea how or why.

When I was still a programmer it was necessary to understand the many characteristics of, and rules about using, the objects that we would place on the screen in an application. Under what conditions did one appear? Physical dimensions, like width and height. Does it have a borderline around it? How wide is that line? Does it have a background color? How about a foreground color? Can it display images, text, both? Where does it get its information, keyboard entry, internal calculation? and on and on and on. Fairly simple and straightforward once one knows how it works. But consider the human brain, with billions of neurons, and a nearly infinite possible range of interactions among them. Somehow, within that biological organ, there is a thing we refer to as consciousness. We are who and what we are, and saying so, thinking so, makes us conscious, at the very least. But how did this gelatinous, gross substance, come to develop awareness of self? And just what is consciousness, anyway?

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Patrick House – image from Attention Fwd ->

Patrick House, a Ph.D. neuroscientist, researcher and writer, offers a wide range of looks at what consciousness might be, mostly by looking at details of the brain. How do the characteristics of zombie food come to be, and how do they combine to create something far greater than a tasty meal for the hungry dead? He looks at many of the currently popular ideas that try to get a handle on the fog that is consciousness.

The book is a collection of possible mechanisms, histories, observations, data, and theories of consciousness told nineteen different ways, as translations of a few moments described in a one-page scientific paper in Nature, published in 1998, titled “Electric Current Stimulates Laughter.” The idea is an homage to a short book of poetry and criticism, Nineteen Ways of Looking at Wang Wei, which takes the poem “Deer Park” by Wang Wei and analyzes nineteen different translations of it in the centuries since it was originally written.

He points out more than once that our brains did not emerge in an instant, all sparkling, from the build-a-brain factory. They evolved, from the very first living cell, so at each step of the evolutionary ladder, whatever traits favored survival and reproduction became dominant, pushing prior adaptations into the DNA equivalent of attic storage. Some of the accretion of the prior adaptations may vanish over time, but bags of the stuff are still lying about.

In tracing how our brains evolved, He points out qualities, like the brain’s need for cadence, and timekeeping, shows that language and action are comparable products of the brain and reports on how speech arose from systems that governed movement. He looks at the brain’s mission of preventing our bodies from losing 1.5 degrees of internal temperature, at how we map out the sensate terrain around us, and at the significance of size in brain complexity.

Imagery runs rampant. There is a chapter on the pinball machine as an appropriate metaphor for consciousness. It was a TILT for me. But ineffective chapters like that one are rare, and can be quickly forgotten when the next chapter offers another fascinating perspective, and bit of evolutionary vision. Another, more effective image, was scientists looking for “surface features” of the brain that might tell us where consciousness lies, like geologists surveying terrain to identify likely ore locations.

Throughout the book House refers to a patient, referred to as Anna, who, while having neurosurgery, had her brain poked in various locations by the surgeon, testing out the function of different parts of her gray matter, prompting some unexpected results. Grounding much of the discussion in the experience of an actual person helped make the material more digestible.

As I read, questions kept popping up like synapses flashing a signal to the next synapse. First of all is a definition of consciousness. What is it? How is it defined? Probably the most we can hope for is to infer its existence from externalities, in the same way that astrophysicists can infer the presence of a black hole by measuring the light coming from nearby objects, without ever being able to actually see the black hole, itself. Is there a measurable range of consciousness? Is entity #1 more or less conscious than entity #2. (Man, that is one seriously self-aware tree) How might we measure such a thing? This is actually addressed in one of the chapters. I would have been interested in more on consciousness in the world of Artificial Intelligence. If programmers put together a sufficient volume of code, with a vast array of memory and data, might there be a possibility of self-awareness? What would it take?

For an item on an electronic screen, one can find out the specific characteristics that comprise it. And with that knowledge, check against a list of possible items it might be. It might be a text-box, or a drop-down menu, or a check-box, a button that triggers an action when clicked. But with the brain, while we can compile a considerable list of characteristics, there is not really a list against we can check those things to arrive at a clear conclusion. Oh yeah, any entity, biological or electronic, that possesses at least some number of certain core characteristics, can be considered to be conscious. Nope, it does not work that way.

I found by the end of the book that I had learned a fair bit about how brains evolved, which is always a wonderful experience, but was as uncertain at the end as at the beginning about just what consciousness is. I expect that House shares that leaning, to at least some degree.

There is no one such thing as “consciousness,” and the attempt to study it as a singular phenomenon will go nowhere.

But he does suggest that consciousness exists as a range of experiences rather than as a singular entity with firmly defined borders. It is a fascinating read, even if the core definition is lacking. One thing is for sure, it is brain candy of the first order whether you are self-aware or not.

And just for fun, for next week’s class, be prepared to discuss the difference between consciousness and the mind.

Review posted – October 29, 2022

Publication date – September 22, 2022

I received an ARE of Nineteen Ways of Looking at Consciousness from St. Martin’s Press in return for a fair review. Thanks, folks.

This review has been cross-posted on GoodReads

=======================================EXTRA STUFF

Links to the House’s personal, and Twitter pages

Items of Interest
—–Wang Wei – Deer Park

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Filed under Non-fiction, Psychology and the Brain, Science and Nature